DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave.

DNA- and RNA-binding proteins (DRBPs) constitute a significant fraction of cellular proteins and have important roles in cells. Their functions include control of transcription and translation, DNA ...

Figure 1: Crystal structure of Cas9 in complex with a sgRNA and a PAM- containing target DNA. Figure 3: Interactions with the +1 phosphodiester group orient the target strand for guide-RNA binding. In ...